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Berberine is a plant alkaloid affecting glucose metabolism at the cellular level, while GLP-1 agonists regulate appetite and insulin secretion through hormone signaling

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The GLP-1-induced enhancement of evoked EPSCs was abolished by a selective GLP-1 receptor antagonist, exendin 939, as well as by the extracellular application of a specific protein kinase A (PKA) inhibitor, KT5720

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