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Side effects may resurface when first increasing, though the intensity varies individually

FDA was notified by Novo Nordisk on Nov

L., Tomaro-Duchesneau, C

STEP 1 (Wilding et al., 2021, New England Journal of Medicine) enrolled 1,961 participants and demonstrated a mean body weight reduction of 14.9% at 68 weeks with 2.4mg subcutaneous semaglutide, the first pharmacological intervention to produce weight loss of this magnitude in a Phase 3 trial, establishing a new efficacy benchmark that became the comparison standard for all subsequent metabolic compounds including Tirzepatide and Retatrutide

Plasma glucose was significantly lower at 52 weeks compared with screening and baseline for the GLP-1RA group, P 0.05

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