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These are only two studies among hundreds of other trusted PRP publications Their findings, while thought-provoking, are not yet universally supported across the broader PRP literature They genuinely represent early directional insights, but are not representative of the data As is the fickle world of published clinical data, a much larger systematic review and meta-analysis of 34 randomised controlled trials by Simental-Menda et al (2025) found no consistent relationship between higher absolute platelet count and better clinical outcomes in knee OA

While some studies showed higher amounts of stomach contents, aspiration events were rare and occurred at rates similar to patients who were not taking the medications

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The retatrutide trials reported a small number of pancreatic events, consistent with the class effect seen in tirzepatide and semaglutide studies

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