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The Physiology of Glucagon-Like Peptide 1

The use of basal insulin is usually considered when using high doses of steroids are used or in those patients with characteristics of diabetes prior to the start of the steroid

GLP-1 medications like Mounjaro (tirzepatide) and Wegovy (semaglutide) reduce hunger and cravings, helping us lose weight by eating fewer calories

Reducing ischemia-reperfusion injury, increasing brain healing, limiting inflammatory response, and oxidative stress are all ways in which GLP-1R activation can lessen the extent of cerebral infarction [131], [132], [133], [134]

Concurrently, GLP-1 also reduces fat build-up in the liver by activating AMPK, which then inhibits fatty acid synthesis while promoting the breakdown of fatty acids (beta-oxidation), leading to less lipid droplet accumulation in hepatocytes

The mental-health data across GLP-1s are still genuinely mixed