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and a Juris Doctor from The Dickinson School of Law, Pennsylvania State University

In the head-to-head SURMOUNT-5 trial (NEJM, 2025), Mounjaro produced 20.2% average weight loss vs 13.7% for Wegovy over 72 weeks

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If you're still in dose escalation (moving from 0.25 mg to 0.5 mg to 1.0 mg, etc.), taking a dose early essentially acts like a smaller dose increase, potentially triggering breakthrough hunger or inconsistent appetite control

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By activating all three pathways, retatrutide promotes significant reductions in appetite, caloric intake, and body weight, and has shown improvements in metabolic markers in clinical trial populations primarily adults with obesity, rather than those with established type 2 diabetes