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Across both programs, researchers tracked adverse events meticulously, documenting everything from nausea to injection site reactions

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Eur J Clin Invest (2003) 33(5):397401.10.1046/j.1365-2362.2003.01161.x 146 HortonFWrightJSmithLHintonPJRobertsonMD

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In one of the key studies known as the STEP 5 trial, participants treated with GLP-1s experienced a mean weight reduction of 15.2% over a two-year period, compared to a 2.6% reduction in the placebo group

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That P value of 0.2 means this increase was not statistically significant at the lowest dose

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Shares in the latter fell sharply after the Hansoh deal was announced, alongside other smaller companies with weight-loss candidates, including Structure Therapeutics and Terns Pharma

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Lower exposures can still produce meaningful changes

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