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Description
In the Phase 2 T2D trial, exploratory analyses showed significant reductions in liver fat content with retatrutide
Activation of TGR5 in brown adipose tissue and skeletal muscle increases energy expenditure, while activation in macrophages inhibits production of pro-inflammatory cytokines (37)
95% CI 0.04, 0.6)
During dose escalation phases, nausea may be more intense and last longer
The case adds to the growing body of GLP-1 litigation
And alcohol impairs judgment around food choices, which undermines the appetite management benefits the medication provides
