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This effect is likely mediated by synergistic interactions between the endogenous cannabinoid system and the endogenous opioid system at both the spinal cord and central nervous system levels [66]

10.1016/j.cjca.2014.03.003 36 HuckD

Unlike patents of addition (under Section 54), which expire with the core patent, these independent secondary patents have their own 20-year terms

LEAP2 ameliorates high fat diet-impaired glucose tolerance and enhances glucose-stimulated insulin secretion from beta cells through PPARgamma signal pathway

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orlistat was given three times a day orally