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People who have not achieved adequate weight loss through diet and lifestyle changes alone

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Clinical trials and pooled analyses have shown that the combination has a safety profile similar to each component alone, with a low incidence of hypoglycemia (unless combined with insulin or sulfonylureas)

Results The levels of GLP-1R decreased significantly in the knees of OA rats, accompanied by the downregulation of PKA /CREB signals and upregulation of inflammation-related proteins

No alternative reversible etiology for bowel obstruction was identified

The first randomised controlled trial of semaglutide for alcohol use disorder, published in JAMA Psychiatry in 2025, found that people taking low doses had fewer heavy drinking days, fewer cravings, and reduced alcohol intake compared to placebo