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Cancer progression due to hyperglycemia was reported in multiple cancers, including breast, colorectal, brain, and pancreatic cancer [22,23,24,25]
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Clinical outcomes were categorized as Positive (demonstrated therapeutic or biomarker benefit), Inconclusive (limited or formulation-dependent evidence), or Neutral (no statistically significant improvement over control)
To understand the multiplexed pharmacological actions of retatrutide, we used cryo-electron microscopy (cryo-EM) to determine the structures of GLP-1R, GIPR and GCGR bound to retatrutide
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Researchers documented striking results in this trial
