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Centrally, GLP-1 receptor activation in the hypothalamus and brainstem suppresses appetite and reduces food intake
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Both compounds target GIP receptors, yet their binding affinities and downstream signaling profiles differ measurably

Gabler M, Picker N, Geier S et al (2021) Real-world clinical outcomes and costs in type 2 diabetes mellitus patients after initiation of insulin therapy: a German claims data analysis
One company is taking them to the Super Bowl so that anyone can try them