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Never double a dose.
A history of severe reflux, bariatric surgery, opioid use, Parkinson disease, scleroderma, gastric outlet obstruction, or long-standing diabetes should raise suspicion for baseline motility impairment

Understanding the documented side effect profile helps researchers design protocols that account for these possibilities

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The cortisol side of this is covered in more detail in how cortisol stalls fat loss on Retatrutide
