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We think orforglipron is a prime candidate for this pilot program as it treats a high-burden chronic condition and can be priced at parity, Jefferies analyst Akash Tewari said in a recent research note

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This helps reduce GI side effects such as nausea, vomiting, constipation, and diarrhea

Though similarities exist in their structure and function, each incretin has some differing effects

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Mild cramping, early fullness or post-meal discomfort is expected early on in treatment or after dose increases and tends to improve with time