glp 1 agonist vs sglt2 inhibitor Inhibitors vs. GLP-1 Agonists to Treat the Heart, the Kidneys and the Brain Blood pressure effects of SGLT2

A recent study from Prime Therapeutics found that nearly half of patients discontinue GLP-1 therapy within the first year, and three out of four stop treatment by year two

Mazdutide overall appears to achieve superior weight loss, in shorter periods of times compared to GLP1R agonists

However, how the pills work in the body differs slightly

Tirzepatide (Mounjaro / Zepbound) Mounjaro and Zepbound contain tirzepatide, a newer agent that targets two hormonal pathways simultaneously, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)

Naunyn-Schmiedebergs Arch Pharmacol (2019) 392:132130

doi: 10.1016/J.OPHTHA.2014.05.013/ATTACHMENT/4DFFCC6A-BE96-4720-96C7-1DA6395D6ECE/MMC5.PDF 75 CuiQNSteinLMFortinSMHayesMR