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Notably, the authors suggested that semaglutide may reduce de novo collagen synthesis without causing degradation of pre-existing collagen fibers [29], implying that semaglutide may not improve existing fibrosis, but it may prevent the initiation and progression of fibrosis, which, however, needs other more focused studies to be definitively demonstrated

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The additional GIP activity enhances insulinotropic effects and may amplify weight loss via both central and peripheral pathways not fully replicated by GLP-1 agonism alone 5

Early Retatrutide data suggests even better lean mass preservation, possibly due to the glucagon components effect on protein metabolism

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