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As exogenous proteins and peptides, venom components can elicit unwanted immune responses, including hypersensitivity and anaphylaxis, particularly upon repeated administration [103,104]

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While early research suggested that nesidioblastosis or beta-cell hyperplasia might be a cause of PPHG after surgery, it is now believed that other factors like altered incretin hormone response, rapid gastric emptying, and changes in insulin sensitivity are more important [31].Some sources suggest that this early theory has been abandoned

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Vitamin B12 does not enhance tirzepatides effects, but for those deficient in B12, correcting that deficiency may help reduce fatigue and support overall health during GLP-1 treatment

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