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Not Eating Enough Exhaustion Lack of hunger doesnt mean your body suddenly stopped needing fuel
The major adverse effects associated with GLP-1 receptor agonist use are nausea and vomiting
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Quick Answer: GLP-1 receptor agonists are not FDA-approved for Crohn's disease and lack clinical trial evidence supporting their use in inflammatory bowel disease

It lowers your metabolism and increases hunger hormones (like ghrelin), making it biologically difficult to maintain weight loss

Second, since January 2026, an FDA-approved oral semaglutide tablet (Wegovy pill) also offers a needle-free option - but that's a prescription pharmaceutical, not a supplement

Nature Communications (2025) 9
