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Metformin's primary mechanism involves activation of AMP-activated protein kinase (AMPK) in hepatocytes, which suppresses gluconeogenesis and significantly reduces hepatic glucose output

1 Heterogeneity of nonalcoholic fatty liver disease

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In the SELECT trial which followed over 17,600 people across several years semaglutide reduced the risk of heart attack, stroke, or cardiovascular death by 20% in adults with existing heart disease and obesity or overweight

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