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Key pharmacological effects include: Glucose-dependent insulin secretion Enhanced pancreatic beta-cell insulin release only when blood glucose is elevated, reducing hypoglycemia risk Suppression of glucagon secretion Decreased hepatic glucose production from pancreatic alpha cells Delayed gastric emptying Slowed movement of food from the stomach to the small intestine Central appetite regulation Reduced hunger and increased satiety through hypothalamic pathways The delayed gastric emptying effect is particularly significant and represents both a therapeutic mechanism and a potential source of adverse effects

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Some started January with real momentum, made progress, and then hit the plateau that most people reach around weeks six to eight - the point where cravings return and the initial results stall

*** This was reported as a composite of death from cardiovascular causes and hospital admission for heart failure

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liraglutide once daily injection showed significant average reduction in Free Fatty Acids (FFA) by (-0.10) and Triglycerides(-0.18) average differ ence over 26 weeks trial over non-significant reductions by Exentide twice daily injection