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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Ben-Menachem E

BPC-157's role in angiogenesis and growth factor modulation may support healthier tissue adaptation during this process
By targeting these receptors, retatrutide mimics the effects of their respective endogenous ligands, glucagon, GIP and GLP-1, which are hormones that regulate glucose metabolism and body weight in various tissues, such as the pancreas, liver, brain, adipose tissue and gastrointestinal tract (Drucker, 2023, Nature)
It also appears to modulate the gastrointestinal side effects of GLP-1 activation, which may explain why tirzepatide is better tolerated despite being more potent

Has demonstrated up to 24% weight reduction over 48 weeks and significant improvements in metabolic risk factors 1,3
