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Inform patients of the potential risk for worsening renal function and explain the associated signs and symptoms of renal impairment, as well as the possibility of dialysis as a medical intervention if renal failure occurs [see Warnings and Precautions (5.6)]

Last reviewed: April 21, 2026

For example, limitations in BBB penetration efficiency allow for limited distribution in the CNS, which may affect efficacy

Also, taking these medications doesnt mean you wont have to make other healthy changes to your day-to-day life

[DOI] [PubMed] [Google Scholar] 11.Wang K., et al

Clinical trials show modest reductions in total cholesterol, LDL-C, and triglycerides correlating with degree of weight loss achieved