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From a clinical perspective, these findings should be interpreted alongside the established cardiometabolic benefits of GLP-1 receptor agonists and the evolving ocular safety literature

Retatrutide is an investigational peptide drug developed by Eli Lilly that acts as a triple agonist, simultaneously targeting three hormone receptors: glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors
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Semaglutide is the active ingredient in GLP-1 receptor agonist medications that reduce the feeling of hunger

Because a GLP-1 targets fat, some patients see facial fat diminish as well

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