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Semaglutide influences multiple body systems, potentially leading to inflammation and joint pain
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Severe gastrointestinal symptoms could also lead to dehydration, which may increase the risk of methotrexate toxicity by affecting renal function

4 According to data from 2021, 10.5% of the population aged 2079 years had diabetes, with almost half unaware of this condition

A helpful overview of how these medications work is covered in what GLP-1 medications are

The STEP trials demonstrated that semaglutide injection produced average weight loss of 15% to 18% over 68 weeks in adults with obesity without diabetes
