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Dual inhibition of the renin-angiotensin system in high-risk diabetes and risk for stroke and other outcomes: results of the ONTARGET trial

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially developed for type 2 diabetes management, have demonstrated remarkable efficacy in addressing the multifactorial pathogenesis of MASLD/MASH [7-10]

doi: 10.1007/s11255-020-02585-w 35 BernardiSMichelliAZuoloGCandidoRFabrisB

These effects were blunted in CNS-specific GIPR knockout mice, suggesting a key role of CNS GIPR in the control of energy metabolism (138) ( Figure 1 Section C)

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