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Diabetes Obesity & Metabolism (2017): Incorporating cardiovascular outcome trials, Monami and colleagues confirmed no significant increase in pancreatitis or pancreatic cancer

doi: 10.2337/db15-0782

These data in conjunction with multiple reports in the 1920s and 1930s that intestinal mucosa had hypoglycemic properties led the authors of both papers to hypothesize that a gut-derived humoral substance contributed to the regulation of insulin secretion (Figure 1)

For example, analyses of healthcare registry data from Europe and North America have tracked thyroid cancer diagnoses among patients using GLP-1 medications

That includes competitor Novo Nordisk's (NVO) semaglutide, which is also part of Lilly's agreement

However, the decision between medication and surgery depends on factors such as BMI, overall health, and individual preferences