gip/glp 1-agonist tirzepatide Frontiers PDB-101: Molecule of the Month:

Description

Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal microglial -endorphin expression

cAMP activates PKA and Epac-2 signal transduction pathways, PKA and Epac-2 lead to the closure of ATP-sensitive potassium channels, which in turn causes depolarization of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of insulin granules and blood glucose control of T2DM patients

New oral GLP-1 drugs could offer more options for weight loss GLP-1 injections require refrigeration and needles

MACE-3, major cardiovascular event (cardiovascular death, nonfatal myocardial infarct, or nonfatal stroke)

Medical professionals face significant challenges when managing patient reactions that display a spectrum of severity from mild rashes and localized urticaria to severe anaphylactic responses [2]