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Glucose oxidase/peroxidase method was used to analyze blood glucose level, enzyme-linked immunosorbent assay for insulin level, and high-performance liquid chromatography for the plasma concentration of the drugs.[ , , ] Study in normal rats Six albino rats of Wistar strain weighing between 250 and 300 g were administered glimepiride (0.09 mg/kg) along with metformin (45 mg/kg) p.o

Schwartz, G.J

That said, most clinicians prefer the combination when possible

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A site of elastase vulnerability was removed by replacing Ser 17 with -methyl-L-serine (MeSer)