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Secondary objectives were change from baseline to week 3 for tirzepatide versus placebo in fasting and postprandial appetite VAS ratings, FCI, FCQ-S, Eating Inventory, PFS questionnaire ratings and BOLD activation to photos of Food HiPal (Food HiF/HiS and Food HiF/HiC ) relative to non-food during the fasting state in the prespecified principal reward ROIs

Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy

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