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Clinical trials for GLP-1 agonists have reported musculoskeletal side effects such as back pain and muscle pain in a small percentage of participants, but joint pain specifically has not emerged as a consistent or significant adverse event across the class

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This may present a risk in situations where these abilities are especially important, such as driving or operating other machinery

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Using GLP-1s for any eating disorders, including anorexia, bulimia or binge eating disorder, is not medically recommended

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