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The Common Side Effects Clinical trials have consistently shown several predictable adverse effects: Gastrointestinal Symptoms These are by far the most common: Nausea Vomiting Diarrhea Constipation Abdominal discomfort These typically decrease as the body adjusts, but they are dose-dependent

Last reviewed: May 14, 2026 Last updated: May 14, 2026 Last reviewed: May 13, 2026 Last updated: May 13, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

doi: 10.1056/NEJMoa2313917

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[16] [12] Use different areas within approved sites : When applying patches to the same general area (such as the abdomen), use a different location within that area for each application, following product-specific guidance

The decision to increase from 8mg to 12mg should be based on individual response, tolerability, and whether additional weight loss is needed to reach goals