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patients titrate up (0.25 0.51.01.72.4 mg weekly)

Effect on satiety

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4.5.2 Early pregnancy exposure: risk characterization under limited data Existing registry, cohort, and systematic-review data have not identified a stable pattern of major structural malformations after brief early-pregnancy exposure to GLP-1RAs, but the exposed human evidence base remains limited and heterogeneous

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27,28 Outside of vascular smooth muscle, the mechanisms by which GLP-1 action can reduce kidney injury are likely multifactorial, 29,30 reflecting that multiple tissues are contributing to improvements