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AbbVies Humira extended-release formulation work illustrates the tension

Pederson RA, Brown JC

Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells
Tirzepatide with niacinamide is another formulation that may have slightly different side effect profiles

2014;306:G622G630

doi: 10.1111/dom.12596
