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The development of dual GIPRGLP1R coagonists that bind to either one or the other receptor (sequence-mixed dual agonists) has emerged as an innovative therapeutic strategy for obesity and type 2 diabetes

This review summarises current understanding of GLP-1RA-induced mitochondrial regulation in the central nervous system

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Monitoring Blood pressure Serum creatinine / eGFR kidney function Serum potassium Losartan = ARB blocks AT1 receptor lowers BP, protects kidneys in diabetics, safer than ACE inhibitors for cough, monitor renal function and potassium.