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Written By: Divyanjali Godage BPharmReviewed By: Pharmacally Editorial Team The OASIS-4 phase 3 trial conducted by Novo Nordisk and published in the New England Journal of Medicine shows that once-daily oral semaglutide 25 mg produces clinically significant weight loss (mean weight loss 13.6% vs 2.2% with placebo at week 64)
The "Non-Negotiable" Rules for Administration: Timing: Patients must take the tablet immediately when they wake up on an empty stomach (having fasted for at least 6 hours overnight)
It enhances insulin secretion, slows gastric emptying, improves lipid profiles, and may offer cardiovascular protection
