is semaglutide still in short supply Drugmakers battle pharmacies over compounded Ozempic and Zepbound : Shots People who take GLP-1 drugs

Description

A new trend has been receiving considerable attention: people using the diabetes drug Semaglutide for weight loss

The 0.9% benzyl alcohol content serves a dual purpose: it prevents microbial proliferation and it extends the usable life of the vial after the first puncture

Semaglutide activates GLP-1 receptors, which increases insulin secretion and decreases glucagon secretion while improving the metabolism of sugars

Both achieve sub-1% bioavailability

Ian Douglas, PhD, BSc, professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine, who was also not involved in the study, pointed out: The time at which someone starts a treatment for obesity can itself be correlated with mental health difficulties, and the effects of the medication on weight, whether this is a dramatic reduction in weight, or a disappointing lack of weight reduction, can also trigger changes in mental health. If we want to know whether GLP-1 agonists cause changes in mental health status, either through their direct pharmacological action or indirectly through their action on weight, we ideally need studies that compare people treated with GLP-1 agonists with similar people not receiving them to see if there are differences in their risk of mental health outcomes. Ian Douglas, PhD, BSc Of the NIH study, Douglas said, I wouldnt go so far as to say GLP-1 agonists prevent mental health problems based on these findings, but the results are certainly not consistent with a harm. Douglas questioned the methodology used in the new study, saying that individual spontaneous reports of suspected adverse drug reactions [] such as those used in the new study are not an appropriate resource in which to test this hypothesis about GLP-1 agonists. Ali expressed a similar concern