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2022;13 doi: 10.3389/fendo.2022.927859

Sepsis often leads to neurological complications such as delirium and sepsis-associated encephalopathy (SAE), which are linked to increased mortality, prolonged intensive care unit stays, and persistent cognitive impairments (49)

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Medications like methotrexate, TNF-alpha inhibitors, and other biologics often show decreased efficacy in patients with higher body weight