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The 833 patent was filed on May 17, 2006, and was granted on February 14, 2012

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Traditionally, the EECs were classified by the peptide they secrete, although more recently, application of RNA sequencing has led us to know that a single EEC can produce multiple hormones within an individual, and different hormonal promoters may be active at different times (90, 91) The distribution of the different EECs across the gastrointestinal tract that is generally accepted is: Stomach: P/D1 cells (ghrelin), D cells (somatostatin), G cells (gastrin), and ECL cells (histamine)

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200 g Fmoc-Gly-Wang Resin (21.6 mmol) with a degree of substitution of 0.108 mmol/g was weighed and swelled for 30 min with DMF, followed by sequentially coupling according to the amino acid sequence of Semaglutide with 2-5 equivalents of amino acid feeds and condensing with DIC+A or B+A+C, until the resin was detected to be transparent with ninhydrin, wherein A was HOBt or HOAt