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Pro-inflammatory cytokines (e.g., IL-1 and TNF), mediators of Th1 and Th17 cells (e.g., IFN and IL-17), and effector mechanisms involving neutrophils, macrophages, and plasma cells are all implicated in the disease process [28, 29]

However, it is considered an important risk factor for weight gain (16, 17) ( Figure 1 )

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That said, it can be more manageable with a few simple strategies

For tirzepatide, it ranges from 5 mg to 15 mg weekly depending on individual response and tolerance