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Description
Data analysis occurred from March to April 2023, with additional analysis in February 2024
This widespread receptor distribution provides a mechanistic basis for the multifaceted effects of GLP-1 RAs on BP reduction (Figure 1)

This risk is heightened during menopause when muscle preservation is already challenged by hormonal changes

Sfikas G, Psallas M, Koumaras C, Imprialos K, Perdikakis E, Doumas M, et al
In the above animal model, cotadutide administration was associated with reduction of hepatic inflammation and fibrosis, as indicated by decreases in quantitative measures of liver fibrosis, circulating collagen markers, and inflammatory/pro-fibrotic genes [39]

This happens because appetite hormones like ghrelinwhich GLP-1 suppressesgradually return to their baseline levels