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These findings indicated that TGF-1 + IL-1 was sufficient to induce fibroblast activation by activating NLRP3 inflammasome, but insufficient to cause NLRP3/caspase-1/GSDMD-mediated fibroblast pyroptosis, while the underlying mechanism remains to be further explored

This phenomenon is particularly pronounced during the first 48 weeks of therapy when gastrointestinal side effects are most intense

, van Gaal, L