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Akkermansia muciniphila produces P9, a small protein that interacts with intercellular adhesion molecule 2 to increase thermogenesis and glucagon-like peptide-1 secretion in mice.

This and other trials have shown improvements in patients lipid profiles with the most pronounced impact on reduction of triglycerides

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and in July 2024, the FDA approved Kisunla (donanemab) for early symptomatic Alzheimers, based on evidence of reduced clinical decline and a limitedduration regimen tied to amyloid plaque removal

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