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Clinical trials have shown that gastrointestinal side effects are among the most common, with nausea reported in 15-20% of patients taking semaglutide for diabetes and up to 44% of those on higher doses for weight management

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However, the long-term treatment with GLP-1RAs may reduce the insulin levels in both T2DM (122) and prediabetic patients (123), owing to the glycemic normalization and increased insulin sensitivity in these patients

Understanding how these medications work is essential context for evaluating their potential effects on bone health, as both their metabolic actions and the weight loss they induce may theoretically influence bone density and skeletal integrity

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