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The results were mixed: in some studies, lean mass was largely stable, while others saw more notable reductions

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A novel triple therapy, retatrutide, could continue the string of game-changing metabolic agents that began with semaglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist for type 2 diabetes and obesity, and continued with tirzepatide, a dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonist

(3) Contraindications History of cardiovascular disease (e.g., coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension) (4) During or within 14 days following the administration of monoamine oxidase inhibitors (4) Hyperthyroidism (4) Glaucoma (4) Agitated states