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7072 Once released into circulation, insulin mediates its anabolic effects on target tissues by binding to its receptor (insulin receptor) on target tissues

[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Pierce-Messick Z., Pratt W.E

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COMBINED USE OF GLP-1RAs AND SGLT-2IS: ANY SYNERGISTIC EFFECTS

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GLP-1R agonists promote CICR in a Ca 2+ -dependent manner, requiring a rapid increase in intracellular free Ca 2+ concentration to mediate Ca 2+ release from intracellular stores [85,89]