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The most common side effects are gastrointestinal, like nausea or constipation, especially when starting or increasing a dose

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A 2021 New England Journal of Medicine study evaluated Semaglutide in a large randomized human study, and a 2023 New England Journal of Medicine study evaluated cardiovascular endpoints in a separate large randomized human study

Clinical trials show that patients who stop semaglutide regain approximately 50-70% of lost weight within one year, while those who continue therapy maintain their weight loss long-term

Strong competition from global giants Patent and intellectual property barriers Supply chain and manufacturing scale What This Means for Patients For patients, especially in the future: More affordable weight-loss and diabetes drugs Increased availability of GLP-1 therapies Better treatment outcomes Dr