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The essential point Apparent tolerance to Wegovy is almost always a normal plateau or the result of practical factors, not true drug resistance

Frontiers in physiology

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Though often mentioned alongside GLP-1, glucagon has a different role in energy regulation

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In clinical trials, participants who took the highest dose of the once-daily pill achieved an average weight loss of 12.4 percent, or 27.3 pounds, after 72 weeks, compared with 2.2 pounds with the placebo