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Allegations in these cases include: Gallbladder injuries, sometimes requiring surgical removal Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION), a condition involving reduced blood flow to the optic nerve that can result in partial or permanent vision loss Neurological complications, including cognitive or coordination issues Not every patient experiences these effects, and manufacturers deny that the drugs are unsafe when used as directed

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JAMA, 311, 7486

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They can be used in conjunction with other anti-diabetic drugs, such as SGLT-2 inhibitors [7]