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doi: 10.2337/dc21-2543 48 HarvengtAAPolleOGMartinMvan MaanenAGattoLLysyPA

The gastrointestinal side effects may also prove more problematic for older adults, particularly those with existing digestive conditions or those taking multiple medications that interact with gut function

In fact, by continuously depriving the liver of esterified fatty acids and inhibiting the hepatic glycolytic pathway, glucagon promotes the production of ketone bodies [41,42,43] Hepatic ketogenesis is boosted as a result, and mitochondrial fatty acid oxidation is improved [14, 43]

Some patients hold at lower doses for longer periods if they are experiencing adequate appetite suppression and weight loss

The oral formula, Rybelsus, is not known to cause fatigue

doi: 10.1126/scitranslmed.aar7047 [DOI] [PubMed] [Google Scholar] 101