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Whereas previous research has demonstrated the feasibility of using peptides to target nuclear hormone receptors 46,47 , to our knowledge, this is the first single molecule that uses a G-protein-coupled-receptor targeting approach to deliver a small-molecule modulator of an ionotropic receptor

Lastly, although many of the beneficial effects attributed to GLP-1 RAs are inferred from established molecular pathways or disease surrogates, it is essential to distinguish between weight-lossmediated and weight-independent geroscience effects

Based on evidence for the contribution of hyperglucagonemia to hyperglycaemia in T2D, research demonstrated the use of glucagon antagonism to improve glycaemic control

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Forest plot of GLP-1 receptor agonists versus comparators on the risk of Pulmonary edema

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