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Because this isnt a quick fix, we recommend committing to at least 3 months for optimal success, though many patients start noticing changes in as little as 2 to 4 weeks

A recent study found that certain GIPR genetic variants that impair both Gs and beta-arrestin 2 recruitment are linked to lower adiposity 38 , suggesting that GIPR effects on body weight involve complex signalling pathways

This is critically important because GLP-1 medications do not cure obesity

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Most protocols divide administration into loading and maintenance phases

For some patients, this can lead to: Difficulty falling asleep Waking up throughout the night Feeling tired but wired One of the main reasons for this is increased stimulation of the nervous system